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US scientists have used bacteria's flagellin to develop a new drug that can protect healthy cells and bone marrow while humans are exposed to nuclear radiation or cancer chemotherapy, and prevent radiation from damaging healthy cells. The results of this study were published in a review edition of the American Journal of Science published on April 11.
Rodriguez Baudrillard, an expert at the Roswell Park Cancer Institute in New York, said that radiation therapy can be used to effectively destroy cancerous cells, but it also has a destructive effect on healthy cells. The new drug they developed protects the gastrointestinal cells and bone marrow of rats and monkeys from radiation and does not reduce the efficacy.
Previous studies have confirmed that cancer cells use gene transcription factors to reproduce more rapidly than normal cells. However, when healthy cells in the viscera interact with benign beneficial bacteria, healthy cells will be converted into the same gene transcription factors, especially the whip proteins in some microorganisms, which will trigger the gene transcription factors. The team cleaned up a number of flagellin proteins and injected them 30 minutes before the rats were exposed to radiation. As a result, the mice that had not been injected died. The injections not only protected the cells of the control mice, but also enabled them to counteract the effects of radiation. Enhanced their immune system. Previously, there has never been a single substance that can have these three effects at the same time. The researchers soon produced a new “CBLB502†that is similar to flagellin, which protects 87% of mice from being exposed to high doses of radiation.
The researchers said that CBLB502 can activate a well-known molecular pathway used by certain cancer cells to avoid death. Animals given a single dose of CBLB502 before receiving radiation therapy can significantly reduce radiation damage to bone marrow and gastrointestinal cells, and prolong Animal survival time. At present, the U.S. Department of Defense has signed a contract to jointly develop drugs that respond to radiation and began conducting human clinical trials starting this summer.
Rodriguez Baudrillard, an expert at the Roswell Park Cancer Institute in New York, said that radiation therapy can be used to effectively destroy cancerous cells, but it also has a destructive effect on healthy cells. The new drug they developed protects the gastrointestinal cells and bone marrow of rats and monkeys from radiation and does not reduce the efficacy.
Previous studies have confirmed that cancer cells use gene transcription factors to reproduce more rapidly than normal cells. However, when healthy cells in the viscera interact with benign beneficial bacteria, healthy cells will be converted into the same gene transcription factors, especially the whip proteins in some microorganisms, which will trigger the gene transcription factors. The team cleaned up a number of flagellin proteins and injected them 30 minutes before the rats were exposed to radiation. As a result, the mice that had not been injected died. The injections not only protected the cells of the control mice, but also enabled them to counteract the effects of radiation. Enhanced their immune system. Previously, there has never been a single substance that can have these three effects at the same time. The researchers soon produced a new “CBLB502†that is similar to flagellin, which protects 87% of mice from being exposed to high doses of radiation.
The researchers said that CBLB502 can activate a well-known molecular pathway used by certain cancer cells to avoid death. Animals given a single dose of CBLB502 before receiving radiation therapy can significantly reduce radiation damage to bone marrow and gastrointestinal cells, and prolong Animal survival time. At present, the U.S. Department of Defense has signed a contract to jointly develop drugs that respond to radiation and began conducting human clinical trials starting this summer.
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