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Hypercholesterolemia directly causes atherosclerosis, eventually leading to death and disabling diseases such as coronary heart disease and stroke. With the change of dietary structure, excessive lipid intake from foods has become the main pathogenic factor that induces cardiovascular and cerebrovascular diseases. The elucidation of the molecular mechanism of cholesterol absorption will provide an important basis for the prevention and treatment of such diseases.
The "Cell Metabolism," an internationally renowned academic journal published on June 4, published the latest research results of Chinese scientists on cholesterol absorption. The Song Baoliang research group of the Institute of Biochemistry and Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, discovered that a protein called NPC1L1 is transported on the surface of cells and cells like a “load truck†and transports extracellular cholesterol. Into the cell, and identified this process is dependent on the intracellular microfilament system and the Clathrin/AP2 protein complex. Of particular importance is that they further elucidated the mechanism of action of the recently marketed cholesterol-reducing drug Ezetimibe, developed by Schering-Plough, and demonstrated that the drug is inhibited by inhibiting the “startup†of the “truck†NPC1L1 protein. Cellular absorption of cholesterol.
This pioneering work is of great significance. It not only reveals the molecular pathways that have long plagued scientists' absorption of cholesterol, but also clarifies the principle of the role of cholesterol-lowering drugs “Yi Shi Chunâ€, and provides a theoretical basis for screening novel cholesterol absorption inhibitors. Basis and experimental basis.
The main authors of this thesis are Ph.D. students Ge Liang and Wang Wei. Their Song Baoliang laboratory mainly conducts cholesterol metabolism control research. They have established a foothold in China and have obtained a series of original results, including the laboratory in August 2007. Cell Metabolism magazine reports on a new cholesterol metabolism regulatory key protein. This series of research breakthroughs has laid an important foundation for the development of new cholesterol-lowering drugs with China's independent intellectual property rights.
The "Cell Metabolism," an internationally renowned academic journal published on June 4, published the latest research results of Chinese scientists on cholesterol absorption. The Song Baoliang research group of the Institute of Biochemistry and Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, discovered that a protein called NPC1L1 is transported on the surface of cells and cells like a “load truck†and transports extracellular cholesterol. Into the cell, and identified this process is dependent on the intracellular microfilament system and the Clathrin/AP2 protein complex. Of particular importance is that they further elucidated the mechanism of action of the recently marketed cholesterol-reducing drug Ezetimibe, developed by Schering-Plough, and demonstrated that the drug is inhibited by inhibiting the “startup†of the “truck†NPC1L1 protein. Cellular absorption of cholesterol.
This pioneering work is of great significance. It not only reveals the molecular pathways that have long plagued scientists' absorption of cholesterol, but also clarifies the principle of the role of cholesterol-lowering drugs “Yi Shi Chunâ€, and provides a theoretical basis for screening novel cholesterol absorption inhibitors. Basis and experimental basis.
The main authors of this thesis are Ph.D. students Ge Liang and Wang Wei. Their Song Baoliang laboratory mainly conducts cholesterol metabolism control research. They have established a foothold in China and have obtained a series of original results, including the laboratory in August 2007. Cell Metabolism magazine reports on a new cholesterol metabolism regulatory key protein. This series of research breakthroughs has laid an important foundation for the development of new cholesterol-lowering drugs with China's independent intellectual property rights.
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